(S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid

Base Information

Chemical Name:(S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid
CAS No.:1445985-09-0
Molecular Formula:C₂₆H₂₉Cl₂N₃O₃
Molecular Weight:502.441
Hs Code.:

Synonyms:(S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid

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Chemical Property of (S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid

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Technology Process of (S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid

There total 18 articles about (S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445985-08-9
(S)-tert-butyl 3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoate

: 1445985-09-0
(S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445985-09-0
(S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; acetic anhydride; sulfuric acid; chromium(VI) oxide / 6 h / 0 - 20 °C

2: sodium hydroxide / dichloromethane; water / 1 h / 0 °C

3: sodium tetrahydroborate / methanol / 1 h / 20 °C

4: hydrogen; rhodium contaminated with carbon / ethyl acetate / 20 °C

5: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 2 h / 0 °C

6: potassium carbonate / acetonitrile / 20 °C

7: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

With chromium(VI) oxide; sodium tetrahydroborate; N-Bromosuccinimide; trimethylsilyl bromide; sulfuric acid; rhodium contaminated with carbon; hydrogen; acetic anhydride; potassium carbonate; acetic acid; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-04-5
tert-butyl 3-(2,5-dichloro-4-formylphenyl)acrylate

: 1445985-09-0
(S)-3-(2,5-dichloro-4-((2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)pyrrolidin-1-yl)methyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2: hydrogen; rhodium contaminated with carbon / ethyl acetate / 20 °C

3: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 2 h / 0 °C

4: potassium carbonate / acetonitrile / 20 °C

5: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; trimethylsilyl bromide; rhodium contaminated with carbon; hydrogen; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308