(R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid

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Chemical Name:(R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid
CAS No.:1422052-32-1
Molecular Formula:C₃₆H₃₃FN₆O₂
Molecular Weight:600.695
Hs Code.:

Synonyms:(R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid

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Chemical Property of (R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid

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Technology Process of (R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid

There total 8 articles about (R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367278-49-7
(3R)-3-amino-4,4-dimethylpentanoic acid

: 1422052-31-0
5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

: 1422052-32-1
(R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid

Guidance literature:: With sodium carbonate; In 2-methyltetrahydrofuran; acetonitrile; at 125 ℃; for 1h; Microwave irradiation;

Reference yield:

: 38186-88-8
2-chloro-5-fluoronicotinic acid

: 1422052-32-1
(R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 0 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.75 h / 0 °C

3.1: hydrazine hydrate / butan-1-ol / 4.5 h / Reflux

4.1: tert.-butylnitrite; Bromoform / 2 h / 61 - 90 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

6.1: potassium acetate / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere

6.2: 1.5 h / 100 °C

7.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.75 h / Inert atmosphere

7.2: 95 °C / Inert atmosphere

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C

9.1: sodium carbonate / acetonitrile; 2-methyltetrahydrofuran / 1 h / 125 °C / Microwave irradiation

With potassium phosphate; tert.-butylnitrite; oxalyl dichloride; Bromoform; potassium acetate; sodium carbonate; potassium carbonate; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 75302-64-6
2-chloro-5-fluoropyridine-3-carboxamide

: 1422052-32-1
(R)-3-((2-(5-fluoro-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.75 h / 0 °C

2.1: hydrazine hydrate / butan-1-ol / 4.5 h / Reflux

3.1: tert.-butylnitrite; Bromoform / 2 h / 61 - 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5.1: potassium acetate / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere

5.2: 1.5 h / 100 °C

6.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.75 h / Inert atmosphere

6.2: 95 °C / Inert atmosphere

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C

8.1: sodium carbonate / acetonitrile; 2-methyltetrahydrofuran / 1 h / 125 °C / Microwave irradiation

With potassium phosphate; tert.-butylnitrite; Bromoform; potassium acetate; sodium carbonate; potassium carbonate; hydrazine hydrate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;