5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

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Chemical Name:5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine
CAS No.:1422052-31-0
Molecular Formula:C₃₀H₂₂FN₅OS
Molecular Weight:519.602
Hs Code.:

Synonyms:5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

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Chemical Property of 5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

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Technology Process of 5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

There total 8 articles about 5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422052-30-9
5-fluoro-3-(4-(methylthio)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

: 1422052-31-0
5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 38186-88-8
2-chloro-5-fluoronicotinic acid

: 1422052-31-0
5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 0.25 h / 0 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.75 h / 0 °C

3.1: hydrazine hydrate / butan-1-ol / 4.5 h / Reflux

4.1: tert.-butylnitrite; Bromoform / 2 h / 61 - 90 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

6.1: potassium acetate / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere

6.2: 1.5 h / 100 °C

7.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.75 h / Inert atmosphere

7.2: 95 °C / Inert atmosphere

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C

With potassium phosphate; tert.-butylnitrite; oxalyl dichloride; Bromoform; potassium acetate; potassium carbonate; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 75302-64-6
2-chloro-5-fluoropyridine-3-carboxamide

: 1422052-31-0
5-fluoro-3-(4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.75 h / 0 °C

2.1: hydrazine hydrate / butan-1-ol / 4.5 h / Reflux

3.1: tert.-butylnitrite; Bromoform / 2 h / 61 - 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5.1: potassium acetate / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere

5.2: 1.5 h / 100 °C

6.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.75 h / Inert atmosphere

6.2: 95 °C / Inert atmosphere

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C

With potassium phosphate; tert.-butylnitrite; Bromoform; potassium acetate; potassium carbonate; hydrazine hydrate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In 2-methyltetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;