(5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol

Base Information

Chemical Name:(5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol
CAS No.:1417526-58-9
Molecular Formula:C₂₁H₂₂F₃N₃O
Molecular Weight:389.42
Hs Code.:

Synonyms:(5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol

Chemical Property:

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Technology Process of (5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol

There total 1 articles about (5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417526-55-6
2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

: 506-59-2
N,N-dimethylammonium chloride

: 1417526-58-9
(5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1417526-58-9
(5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol

: 1424335-45-4
C₂₁H₂₁F₃N₆

Guidance literature:: With diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Reflux;
DOI:10.1016/j.bmcl.2013.01.029

Reference yield:

: 1417526-58-9
(5-((dimethylamino)methyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazol-2-yl)methanol

: 1424335-28-3
C₂₁H₂₃F₃N₄

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / Reflux

2: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

With diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; water; 2: |Staudinger Azide Reduction;
DOI:10.1016/j.bmcl.2013.01.029