2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

Base Information

Chemical Name:2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde
CAS No.:1417526-55-6
Molecular Formula:C₁₉H₁₅F₃N₂O₂
Molecular Weight:360.336
Hs Code.:

Synonyms:2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

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Chemical Property of 2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

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Technology Process of 2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

There total 6 articles about 2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 312936-81-5
1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

: 1417526-55-6
2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

Guidance literature:: In 1,4-dioxane; for 36h;
DOI:10.1016/j.bmcl.2013.03.062

Reference yield:

: 312936-77-9
1-(4-Bromobenzyl)-2-Mercapto-5-Hydroxymethylimidazole

: 1417526-55-6
2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; acetic acid / dichloromethane / 0.33 h / 35 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 12 h / Reflux; Inert atmosphere

3: manganese(IV) oxide / 1,4-dioxane / 3 h / 60 °C

4: 1,4-dioxane / 36 h

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; caesium carbonate; acetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2013.03.062

Reference yield:

: 106-40-1
4-bromo-aniline

: 1417526-55-6
2-(hydroxymethyl)-1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / acetonitrile / 0.05 h / Cooling with ice

1.2: 2 h / 70 °C

2.1: dihydrogen peroxide; acetic acid / dichloromethane / 0.33 h / 35 °C

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 12 h / Reflux; Inert atmosphere

4.1: manganese(IV) oxide / 1,4-dioxane / 3 h / 60 °C

5.1: 1,4-dioxane / 36 h

With hydrogenchloride; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; caesium carbonate; acetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.062