ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate

Base Information

• Chemical Name: ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate
• CAS No.: 1363375-82-9
• Molecular Formula: C₂₇H₃₁FN₂O₆S
• Molecular Weight: 530.617
• Mol file: 1363375-82-9.mol

Synonyms:ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate

Chemical Property of ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate

There total 8 articles about ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl [2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methanesulphonylphenyl)-1H-pyrrol-3-yl]]-acetate (1363375-41-0) → ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate (1363375-82-9)

Guidance literature:

In methanol; for 18h;

DOI:10.1016/j.ejmech.2012.10.014

Reference yield: 57.0%

ethanol (64-17-5) + di-tert-butyl dicarbonate (24424-99-5) + 2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetic acid (1363375-83-0) → ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate (1363375-82-9)

Guidance literature:

at 20 ℃; for 18h;

Reference yield:

ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate → ethyl N-tert-butoxycarbonyl-2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]acetate (1363375-82-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; 1,4-dioxane / 40 h / 90 °C

2: zinc; formic acid / ethanol / 0 - 20 °C

3: methanol / 18 h

With formic acid; hydroxylamine hydrochloride; sodium acetate; zinc; In 1,4-dioxane; methanol; ethanol;

DOI:10.1016/j.ejmech.2012.10.014

upstream raw materials:

di-tert-butyl dicarbonate

ethyl [2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methanesulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

ethyl 2-hydroxy-imino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]-acetate

Downstream raw materials:

(R,S)-N-tert-butoxycarbonyl-1-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-3-[2-(2-tetrahydro-2H-pyran-2-yloxy)ethoxy]]ethyl-1H-pyrrole

N-tert-butoxycarbonyl-1-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrolo-3-yl]ethanol

N-(tert-butoxycarbonyl)-2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]-2-amino-acetic acid

4-(nitrooxy)butyl-[2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methylsulphonylphenyl)-1H-pyrrol-3-yl]]-acetate