6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide

Base Information

Chemical Name:6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide
CAS No.:1446790-75-5
Molecular Formula:C₂₀H₂₇N₇O
Molecular Weight:381.481
Hs Code.:

Synonyms:6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide

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Chemical Property of 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide

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Technology Process of 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide

There total 7 articles about 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.1%

: 1446792-31-9
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-cyclobutylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

: 1446790-75-5
6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 372118-01-9
4,6-dichloro-pyridazine-3-carboxylic acid methyl ester

: 1446790-75-5
6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 48 h / 80 °C / Sealed tube

2: ammonia / methanol / 18 h / 20 °C

3: 1-methyl-pyrrolidin-2-one / 72 h / 120 °C

4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With ammonia; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;

Reference yield:

: 83878-89-1
2-diazo-3-oxo-pentanedioic acid dimethyl ester

: 1446790-75-5
6-((1R,2S)-2-aminocyclohexylamino)-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / diethyl ether / 24 h / 20 °C

1.2: 10 h / Reflux

2.1: trichlorophosphate / 5 h / 95 °C

3.1: acetonitrile / 48 h / 80 °C / Sealed tube

4.1: ammonia / methanol / 18 h / 20 °C

5.1: 1-methyl-pyrrolidin-2-one / 72 h / 120 °C

6.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With ammonia; triphenylphosphine; trifluoroacetic acid; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; acetonitrile;