(1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

Base Information

Chemical Name:(1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester
CAS No.:852660-35-6
Molecular Formula:C₂₉H₃₉FN₂O₄
Molecular Weight:498.638
Hs Code.:

Synonyms:(1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

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Chemical Property of (1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

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Technology Process of (1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

There total 11 articles about (1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852660-34-5
(1R,2S)-[2-({[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 852660-35-6
(1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

Guidance literature:: In tetrahydrofuran;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852660-35-6
(1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: sodium hydroxide; water / methanol / Heating / reflux

2.2: pH 1

3.1: thionyl chloride / dichloromethane / 24 h / 25 °C

4.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

7.1: tetrahydrofuran

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 852660-35-6
(1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

3.2: 1 h

4.1: pyridine / 168 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

8.1: tetrahydrofuran

With pyridine; lithium aluminium tetrahydride; sodium azide; hydrogen; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;