t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate.

Base Information

• Chemical Name: t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate.
• CAS No.: 716359-47-6
• Molecular Formula: C₂₃H₃₂N₂O₅
• Molecular Weight: 416.517

Synonyms:t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate.

Chemical Property of t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate.

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate.

There total 3 articles about t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate (193537-11-0) + m-ethoxyphenyl bromide (2655-84-7) → t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate. (716359-47-6)

Guidance literature:

m-ethoxyphenyl bromide; With magnesium; In diethyl ether; at 20 ℃; Inert atmosphere;

tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate; With copper(l) iodide; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm200279v

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate. (716359-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / benzene / 4 h / Dean Stark conditionsarkness; Reflux

2.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With ammonium acetate; magnesium; acetic acid; In diethyl ether; benzene;

DOI:10.1021/jm200279v

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → t-butyl 4-(1-cyano-2-ethoxy-2-oxoethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate. (716359-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / benzene / 4 h / Dean Stark conditionsarkness; Reflux

2.1: magnesium / diethyl ether / 20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With ammonium acetate; magnesium; acetic acid; In diethyl ether; benzene;

DOI:10.1021/jm200279v

upstream raw materials:

tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

m-ethoxyphenyl bromide

N-tert-butyloxycarbonylpiperidin-4-one

ethyl 2-cyanoacetate

Downstream raw materials:

t-butyl 4-(cyanomethyl)-4-(3-ethoxyphenyl)piperidine-1-carboxylate

t-butyl 4-(3-ethoxyphenyl)-4-(2-oxoethyl)piperidine-1-carboxylate

t-butyl 4-(3-ethoxyphenyl)-4-{2-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]ethyl}piperidine-1-carboxylate.

t-butyl endo 4-(3-isopropoxyphenyl)-4-{2-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo [3.2.1]oct-8-yl]ethyl}piperidine-1-carboxylate

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