Technology Process of N-((2R,3S)-2-But-3-enyl-4-oxo-azetidin-3-yl)-2-phenoxy-acetamide
There total 13 articles about N-((2R,3S)-2-But-3-enyl-4-oxo-azetidin-3-yl)-2-phenoxy-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium tri(t-butoxy)aluminum hydride;
In
tetrahydrofuran;
at 0 ℃;
Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)93376-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 124 g / pyridoxal phosphate; serine hydroxymethyltransferase from E. coli; ammonium hydroxide / H2O / 5 h / 15 °C / pH 6.9 - 7.1
2: 97 percent / aq. NaOH / 5 - 10 °C / pH 9.0 - 9.5
3: 95 percent / NH3; t-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0 - 20 °C
4: 88.2 percent / 2,6-lutidine / CH2Cl2 / 3 h / 20 °C
5: 95 percent Chromat. / ClSO3H; 2,6-lutidine / CH2Cl2 / 5 h / -15 - -10 °C
6: 1.02 g / aq. KOH / 2.5 h / 0 - 20 °C / pH 10.0
7: 96.9 percent / conc. HCl / tetrahydrofuran / 1.17 h / 5 - 7 °C
With
4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; chlorosulfonic acid; potassium hydroxide; ammonium hydroxide; sodium hydroxide; serine hydroxymethyltransferase from E. coli; pyridoxal 5'-phosphate; ammonia; tert-butyl chloroformate;
In
tetrahydrofuran; dichloromethane; water;
1: Condensation / 2: Acylation / 3: Substitution / 4: Substitution / 5: Substitution / 6: Cyclization / 7: Substitution;
DOI:10.1016/S0040-4020(00)00416-6
