tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane

Base Information

• Chemical Name: tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane
• CAS No.: 207737-08-4
• Molecular Formula: C₁₈H₂₉NOSSi
• Molecular Weight: 335.586
• Mol file: 207737-08-4.mol

Synonyms:tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane

Chemical Property of tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane

There total 5 articles about tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 5-tert-butyl-2-methyl-4-thiocyanatophenol (207737-07-3) → tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane (207737-08-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 24h;

DOI:10.1016/S0960-894X(99)00360-1

Reference yield:

4-tert-butyltoluene (98-51-1) → tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane (207737-08-4)

Guidance literature:

Multi-step reaction with 5 steps

1: HNO₃, H₂SO₄ / 18.5 h / 20 - 60 °C

2: H₂ / Pd/C / 2585.74 Torr / Ambient temperature

3: 94 percent / NaNO₂, aq. H₂SO₄ / 70 °C

4: 71 percent / NaBr, Br₂ / methanol / 0 - 20 °C

5: 98 percent / imidazole / dimethylformamide / 24 h

With 1H-imidazole; sulfuric acid; hydrogen; bromine; nitric acid; sodium bromide; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00360-1

Reference yield:

4-tert-butyl-2-nitrotoluene (62559-08-4) → tert-butyl-(5-tert-butyl-2-methyl-4-thiocyanato-phenoxy)-dimethyl-silane (207737-08-4)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd/C / 2585.74 Torr / Ambient temperature

2: 94 percent / NaNO₂, aq. H₂SO₄ / 70 °C

3: 71 percent / NaBr, Br₂ / methanol / 0 - 20 °C

4: 98 percent / imidazole / dimethylformamide / 24 h

With 1H-imidazole; sulfuric acid; hydrogen; bromine; sodium bromide; sodium nitrite; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00360-1

upstream raw materials:

tert-butyldimethylsilyl chloride

5-tert-butyl-2-methyl-4-thiocyanatophenol

4-tert-butyltoluene

5-(tert-butyl)-2-methylphenol

Downstream raw materials:

2-tert-butyl-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-benzenethiol

toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxy-5-methylphenyl) ester

toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-phenyl] ester