Technology Process of {(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}-methanol
There total 12 articles about {(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}-methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane; toluene;
at -78 ℃;
for 1h;
DOI:10.1021/jo0608725
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating
2: 0.308 g / m-chloroperoxybenzoic acid / CH2Cl2 / 2 h / -15 °C
3: 0.192 g / KOH / dimethylsulfoxide; H2O / 18 h / 140 °C
4: triethylamine / tetrahydrofuran / 4 h / 20 °C
5: 4-(dimethylamino)pyridine; N,N-diisopropylethylamine / CH2Cl2 / 72 h / 20 °C
6: 1.17 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
7: 98 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; molecular sieves 4 Angstroem / CH2Cl2 / 3 h / 20 °C
8: 81 percent / LHMDS / tetrahydrofuran / 2 h / -45 °C
9: 87 percent / triethylamine; PdCl2(PPh3)2 / dimethylformamide / 18 h / 55 °C / 18100.2 Torr
10: 79 percent / DIBAL-H / CH2Cl2; toluene / 1 h / -78 °C
With
dmap; bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0608725
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 0.062 g / NaOH / methanol; H2O / 18 h / 20 °C
2: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating
3: 0.308 g / m-chloroperoxybenzoic acid / CH2Cl2 / 2 h / -15 °C
4: 0.192 g / KOH / dimethylsulfoxide; H2O / 18 h / 140 °C
5: triethylamine / tetrahydrofuran / 4 h / 20 °C
6: 4-(dimethylamino)pyridine; N,N-diisopropylethylamine / CH2Cl2 / 72 h / 20 °C
7: 1.17 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
8: 98 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; molecular sieves 4 Angstroem / CH2Cl2 / 3 h / 20 °C
9: 81 percent / LHMDS / tetrahydrofuran / 2 h / -45 °C
10: 87 percent / triethylamine; PdCl2(PPh3)2 / dimethylformamide / 18 h / 55 °C / 18100.2 Torr
11: 79 percent / DIBAL-H / CH2Cl2; toluene / 1 h / -78 °C
With
dmap; bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; sodium hydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo0608725
![(1R,3aR,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-indene-4-carboxylic acid methyl ester](/Databaselist/images/loading.webp)
