(3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene

Base Information

Chemical Name:(3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene
CAS No.:908255-70-9
Molecular Formula:C₂₁H₃₀O₂
Molecular Weight:314.468
Hs Code.:

Synonyms:(3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene

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Chemical Property of (3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene

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Technology Process of (3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene

There total 3 articles about (3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 908255-69-6
(S)-2-((1R,7aR)-7a-Methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-propan-1-ol

: 824-94-2
p-methoxybenzyl chloride

: 908255-70-9
(3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; for 18h; Heating;
DOI:10.1021/jo0608725

Reference yield:

: 64190-55-2
Benzoic acid (S)-2-((1R,7aR)-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-propyl ester

: 908255-70-9
(3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene

Guidance literature:: Multi-step reaction with 2 steps

1: 0.062 g / NaOH / methanol; H₂O / 18 h / 20 °C

2: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo0608725

Reference yield:

: (S)-2-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyloctahydro-1H-inden-1-yl)propyl benzoate

: 908255-70-9
(3R,3aR)-3-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methyl-2,3,3a,4,5,6-hexahydro-1H-indene

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 18 h / Heating

2: 0.062 g / NaOH / methanol; H₂O / 18 h / 20 °C

3: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo0608725