(5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide

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Chemical Name:(5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide
CAS No.:1419598-62-1
Molecular Formula:C₂₆H₂₁ClF₃N₅O₂
Molecular Weight:527.933
Hs Code.:

Synonyms:(5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide

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Chemical Property of (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide

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Technology Process of (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide

There total 7 articles about (5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1254713-79-5
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

: 1419603-12-5
2-(6-(phenylcarbamoyl)pyridin-3-yl)propanoic acid

: 1419598-62-1
(5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide

Guidance literature:: 2-(6-(phenylcarbamoyl)pyridin-3-yl)propanoic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 23 ℃; for 1h; Inert atmosphere;

(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine; With triethylamine; In dichloromethane; at 23 ℃; for 48h;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419598-62-1
(5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 3 h / Reflux

2.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

4.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h / 23 °C / Inert atmosphere

5.2: 48 h / 23 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; ammonia; hydrogen; potassium iodide; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1419598-62-1
(5-(1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methylamino)-1-oxopropan-2-yl)-N-phenyl)picolinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 5 h / -5 - 0 °C

2.1: ethanol / 5 h / Reflux

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

4.1: triethylamine / toluene / 20 h / 80 °C

5.1: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

6.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h / 23 °C / Inert atmosphere

6.2: 48 h / 23 °C

With hydrogenchloride; N-chloro-succinimide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; ammonia; hydrogen; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;