N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide

Base Information

• Chemical Name: N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide
• CAS No.: 354112-92-8
• Molecular Formula: C₂₁H₂₈NOP
• Molecular Weight: 341.433
• Mol file: 354112-92-8.mol

Synonyms:N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide

Chemical Property of N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide

There total 6 articles about N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formic acid (64-18-6) + (S)-N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-methyl-benzamide (354112-89-3) → N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide (354112-92-8)

Guidance literature:

formic acid; With acetic anhydride; at 60 ℃; for 2h;

(S)-N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-methyl-benzamide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/S0957-4166(01)00137-9

Reference yield:

(S)-2-(N-tert-butoxycarbonylamino)-3-methylbutyl tosylate (122818-28-4) → N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide (354112-92-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Li / tetrahydrofuran / 12 h / 20 °C

1.2: 71 percent / t-BuCl / tetrahydrofuran / -78 - 20 °C

2.1: 97 percent / DABCO / toluene / 12 h / 40 °C

3.1: 93 percent / CF₃CO₂H / CH₂Cl₂ / 2 h / 20 °C

4.1: Al₂O₃ / 12 h / 20 °C

5.1: 100 mg / LiAlH₄ / tetrahydrofuran / 12 h / Heating

6.1: (CH₃CO)2O / 2 h / 60 °C

6.2: 99 percent / tetrahydrofuran / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; aluminum oxide; lithium aluminium tetrahydride; acetic anhydride; lithium; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/S0957-4166(01)00137-9

Reference yield:

(2S)-1-(diphenylphosphino)-3-methylbutan-2-amine (146476-37-1,1400149-69-0) → N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide (354112-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Al₂O₃ / 12 h / 20 °C

2.1: 100 mg / LiAlH₄ / tetrahydrofuran / 12 h / Heating

3.1: (CH₃CO)2O / 2 h / 60 °C

3.2: 99 percent / tetrahydrofuran / 0 - 20 °C

With aluminum oxide; lithium aluminium tetrahydride; acetic anhydride; In tetrahydrofuran;

DOI:10.1016/S0957-4166(01)00137-9

upstream raw materials:

formic acid

(S)-N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-methyl-benzamide

(S)-2-(N-tert-butoxycarbonylamino)-3-methylbutyl tosylate

(2S)-1-(diphenylphosphino)-3-methylbutan-2-amine