(2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane

Base Information

Chemical Name:(2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane
CAS No.:858666-87-2
Molecular Formula:C₃₅H₄₆O₄Si
Molecular Weight:558.833
Hs Code.:

Synonyms:(2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane

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Chemical Property of (2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane

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Technology Process of (2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane

There total 26 articles about (2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 852244-95-2
(2S,9S,10S)-1-Benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2,9-bis-(4-methoxy-benzyloxy)-10-methyl-undecan-5-one

: 858666-87-2
(2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 20 ℃; for 1.5h; pH=7;
DOI:10.1021/ol0504291

Reference yield: 84.0%

: 858666-85-0
(2S,9S,10S)-(-)-1-benzyloxy-2,9-bis-(tert-butyldimethylsilyloxy)-11-(tert-butyldiphenylsilyloxy)-10-methylundecane-5-one

: 858666-87-2
(2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 80 ℃;
DOI:10.1021/ol0507975

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 858666-87-2
(2S,5S,7S,1''S)-(+)-2-(1'-benzyloxymethyl)-7-{2''-(tert-butyldiphenylsilyloxy)-1''-methylethyl}-1,6-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 70 percent / Ag₂O

2.1: AlMe₃ / CH₂Cl₂; hexane / 0.33 h / 0 °C

3.1: 1.14 g / camphorsulfonic acid / CH₂Cl₂ / 20 °C

4.1: tert-butyllithium / pentane; diethyl ether / 1.17 h / -78 - 0 °C

4.2: 72 percent / pentane; diethyl ether / 3 h / 0 °C

5.1: 92 percent / DDQ / CH₂Cl₂; H₂O / 1.5 h / 20 °C / pH 7

With camphor-10-sulfonic acid; trimethylaluminum; tert.-butyl lithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In diethyl ether; hexane; dichloromethane; water; pentane;
DOI:10.1021/ol0504291