1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate
CAS No.:1204535-19-2
Molecular Formula:C₁₈H₂₅N₃O₄S
Molecular Weight:379.48
Hs Code.:

Synonyms:1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

There total 4 articles about 1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1204535-18-1
1,1-dimethylethyl (2S)-4-[(4-bromo-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

: 1204535-19-2
1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

Guidance literature:: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis(diphenylphosphino)ferrocene; In N,N-dimethyl-formamide; at 120 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1251110-16-3
4-cyano-2-methylbenzenesulfonyl chloride

: 169447-70-5
(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1204535-19-2
1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

Reference yield:

: 583-75-5
4-Bromo-2-methylaniline

: 1204535-19-2
1,1-dimethylethyl (2S)-4-[(4-cyano-2-methylphenyl)sulfonyl]-2-methyl-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-methyl-pyrrolidin-2-one / 2.5 h / 200 °C

2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0.75 h / 0 - 5 °C

2.2: 10 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1-methyl-pyrrolidin-2-one; dichloromethane; water;