1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Base Information

• Chemical Name: 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol
• CAS No.: 345632-85-1
• Molecular Formula: C₁₅H₂₇NO₂Si
• Molecular Weight: 281.47
• Mol file: 345632-85-1.mol

Synonyms:1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Chemical Property of 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

There total 2 articles about 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

1-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenyl)-propan-2-ol (345632-84-0) → 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol (345632-85-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(01)00047-6

Reference yield:

3-(2-Nitro-phenyl)-propane-1,2-diol (211935-16-9) → 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol (345632-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80.5 percent / imidazole / dimethylformamide / 0.75 h / 0 °C

2: 95.3 percent / H₂ / 10 percent Pd/C / methanol / 0.83 h / 20 °C / 760 Torr

With 1H-imidazole; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00099-6

Reference yield: 71.2%

benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate (131423-64-8) + 1-(2-amino-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol (345632-85-1) → 2-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-phenylamino}-3-methyl-butyric acid benzyl ester (345632-86-2)

Guidance literature:

With 2,6-dimethylpyridine; In 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(01)00047-6

upstream raw materials:

1-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenyl)-propan-2-ol

3-(2-Nitro-phenyl)-propane-1,2-diol

Downstream raw materials:

2-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-phenylamino}-3-methyl-butyric acid benzyl ester