p-Aminobenzylchloride

Base Information

• Chemical Name: p-Aminobenzylchloride
• CAS No.: 65581-19-3
• Molecular Formula: C7H8ClN
• Molecular Weight: 141.6
• Hs Code.: 2921420090
• Mol file: 65581-19-3.mol

Synonyms:4-(Chloromethyl)aniline;4-(Chloromethyl)benzenamine;4-Aminobenzyl chloride;p-(Chloromethyl)aniline;p-Amino-a-chlorotoluene;

Chemical Property of p-Aminobenzylchloride

Chemical Property:

• Boiling Point: 257.6 °C at 760 mmHg
• PKA: 4.28±0.10(Predicted)
• Flash Point: 109.6 °C
• PSA: 26.02000
• Density: 1.185 g/cm³
• LogP: 2.58880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-Aminobenzylchloride

There total 1 articles about p-Aminobenzylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-nitrobenzyl chloride (100-14-1) → 4-aminobenzyl chloride (65581-19-3)

Guidance literature:

With hydrazine; Montmorillonite; In ethanol; for 2h; Heating;

DOI:10.1016/S0040-4039(00)88759-6

Reference yield: 83.0%

3',6'-bis(ethylamino)-2',7'-dimethyl-2-(2-oxoethylideneamino)spiro[isoindoline-1,9'-xanthen]-3-one (1196455-45-4) + 4-aminobenzyl chloride (65581-19-3) → C35H34ClN5O2 (1309581-24-5)

Guidance literature:

at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 78.4%

7-hydroxyl-4,5-dihydrotetrazolo[1,5-a]quinolin (1402548-93-9) + 4-aminobenzyl chloride (65581-19-3) → 7-(4-aminobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline (1352080-35-3)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1007/s00044-011-9922-8

upstream raw materials:

4-nitrobenzyl chloride

Downstream raw materials:

8-hydroxyquinoline-4-(N-p-chloromethylphenyl)sulphonamide

7-(4-aminobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline

C₃₅H₃₄ClN₅O₂

4-Amino-thiobenzoesaeuredimethylamid

Refernces

• 1、 -. "TARGETED PEPTIDE CONJUGATES". Paragraph 0168. . Retrieved 2018/08/12.
• 2、 Long, Yu,Yuan, Bing,Niu, Jianrui,Tong, Xin,Ma, Jiantai. "Distinctive size effects of Pt nanoparticles immobilized on Fe3O4@PPy used as an efficient recyclable catalyst for benzylic alcohol aerobic oxidation and hydrogenation reduction of nitroaromatics". . p. 1179 - 1185. Retrieved 2015/02/19.