3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid

Base Information

Chemical Name:3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid
CAS No.:1258595-14-0
Molecular Formula:C₂₉H₃₂F₂N₃O₇P
Molecular Weight:603.56
Hs Code.:

Synonyms:3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid

There total 13 articles about 3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268527-08-7
ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

: 1258595-14-0
3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid

Guidance literature:: ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃;

With sodium hydroxide; In ethanol; at 80 ℃; for 3h;

Reference yield:

: 740806-51-3
tert-butyl (5-bromo-2-chlorophenyl)carbamate

: 1258595-14-0
3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; acetonitrile; hexane / 20 - 100 °C / Inert atmosphere

2: Wilkinson's catalyst; hydrogen / ethanol; ethyl acetate / 24 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 20 - 100 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium hydrogencarbonate / butan-1-ol; water / 20 - 100 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 24 h

6: hydrogenchloride / 1,4-dioxane; ethanol

7: caesium carbonate / N,N-dimethyl-formamide / 60 °C

8: sodium hydroxide; trimethylsilyl bromide / ethanol; dichloromethane / 3 h / 0 - 80 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Wilkinson's catalyst; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1258595-14-0
3-(5-amino-2-(4-(2-(3,3-difluoro-3-phosphonopropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C

1.2: 3.5 h / 20 °C

2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water; diethyl ether / 20 - 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.75 h / 0 - 20 °C

4.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 - 60 °C / Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium hydrogencarbonate / butan-1-ol; water / 20 - 100 °C

6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 24 h

7.1: hydrogenchloride / 1,4-dioxane; ethanol

8.1: caesium carbonate / N,N-dimethyl-formamide / 60 °C

9.1: sodium hydroxide; trimethylsilyl bromide / ethanol; dichloromethane / 3 h / 0 - 80 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trimethylsilyl bromide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydrogencarbonate; caesium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; butan-1-ol;