ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

Base Information

Chemical Name:ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate
CAS No.:1268527-08-7
Molecular Formula:C₃₅H₄₄F₂N₃O₇P
Molecular Weight:687.721
Hs Code.:

Synonyms:ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

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Chemical Property of ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

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Technology Process of ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

There total 14 articles about ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268526-91-5
diethyl (3-(2-bromoethoxy)-1,1-difluoropropyl)phosphonate

: 1258595-07-1
ethyl 3-(5-amino-2-(4-hydroxy-2-methylphenethyl)benzo[f]-[1,7]naphthyridin-8-yl)propanoate

: 1268527-08-7
ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h;

Reference yield:

: 1478-53-1
Diethyl difluoromethylphosphonate

: 1268527-08-7
ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / cyclohexane; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran / 1 h / Cooling with acetone-dry ice

1.2: 3 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 60 °C

With n-butyllithium; caesium carbonate; diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; cyclohexane; N,N-dimethyl-formamide;

Reference yield:

: 740806-51-3
tert-butyl (5-bromo-2-chlorophenyl)carbamate

: 1268527-08-7
ethyl 3-(5-amino-2-(4-(2-(3-(diethoxyphosphoryl)-3,3-difluoropropoxy)ethoxy)-2-methylphenethyl)benzo[f][1,7]naphthyridin-8-yl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; acetonitrile; hexane / 20 - 100 °C / Inert atmosphere

2: Wilkinson's catalyst; hydrogen / ethanol; ethyl acetate / 24 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 20 - 100 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium hydrogencarbonate / butan-1-ol; water / 20 - 100 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 24 h

6: hydrogenchloride / 1,4-dioxane; ethanol

7: caesium carbonate / N,N-dimethyl-formamide / 60 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Wilkinson's catalyst; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;