6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Base Information

Chemical Name:6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
CAS No.:1560987-57-6
Molecular Formula:C₂₀H₁₈F₂N₄OS₂
Molecular Weight:432.518
Hs Code.:

Synonyms:6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

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Chemical Property of 6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

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Technology Process of 6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

There total 3 articles about 6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 462-72-6
4-bromo-1-fluorobutane

: 1560987-49-6
3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-6-thiol

: 1560987-57-6
6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.0833333h; Temperature; Microwave irradiation;
DOI:10.1007/s00044-014-0944-x

Reference yield:

: 1253043-52-5
C₁₅H₁₁FN₂O₂S

: 1560987-57-6
6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 6 h / Reflux

2: potassium hydroxide / ethanol / 4 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 50 °C / Microwave irradiation

With hydrazine hydrate; potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/s00044-014-0944-x

Reference yield:

: 1401008-58-9
4-amino-5-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl]-4H-1,2,4-triazole-3-thiol

: 1560987-57-6
6-[(4-fluorobutyl)sulfanyl]-3-[5'-fluoro-2'-methoxy-(1,1'-biphenyl)-3-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 4 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 50 °C / Microwave irradiation

With potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/s00044-014-0944-x