Chemical Property of Chlorfenapyr
Chemical Property:
- Appearance/Colour:off-white to light brown powder with an halide odor
- Vapor Pressure:4.6E-08mmHg at 25°C
- Melting Point:100.5oC
- Refractive Index:1.559
- Boiling Point:443.5 °C at 760 mmHg
- PKA:-18.00±0.70(Predicted)
- Flash Point:222 °C
- PSA：37.95000
- Density:1.53 g/cm3
- LogP:5.45548
- Storage Temp.:0-6°C
- Water Solubility.:Insoluble in water
- XLogP3:4.5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:405.96954
- Heavy Atom Count:23
- Complexity:448
- Purity/Quality:
-
98%tc *data from raw suppliers
Chlorfenapyr *data from reagent suppliers
Safty Information:
- Pictogram(s):
T,
N
- Hazard Codes:T;N,N,T
- Statements:
22-23-50/53
- Safety Statements:
13-36/37-45-60-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Pesticides -> Other Insecticides
- Canonical SMILES:CCOCN1C(=C(C(=C1C(F)(F)F)Br)C#N)C2=CC=C(C=C2)Cl
-
Description
Chlorfenapyr is a broad spectrum pesticide which is not approved for use in the EU, and only approved for limited applications in the US (applications for ornamental plants in greenhouses). It was originally rejected for FDA approval due to avian and aquatic toxicity. Data on human toxicity is still scarce, but it has moderate mammalian toxicity when taken orally, causing vacuolation of the nervous system in mice and rats. It is not persistent in ecosystems, and has low aqueous solubility.
Chlorfenapyr can also be used as an insect-proofing agent in wool, and has been investigated for applications in malaria control. Chlorfenapyr is a pyrrole pro-insecticide that is metabolized in vivo into CL 303268 by mixed function oxidases. Chlorfenapyr increases respiratory activity in German cockroaches when used at concentrations ranging from 1 to 10 μg per insect but has no effect on respiration in Sf9 cells when used at concentrations ranging from 1 to 100 μM and does not affect respiration in isolated rat liver mitochondria up to a concentration of 10 μM. Chlorfenapyr is active against a variety of insects including those susceptible and resistant to pyrethroid and organophosphate insecticides, including horn flies (H. irritans) as well as A. culicifacies and A. stephensi mosquitos that carry malaria (LC50s = 2-2.39% suspension impregnated on paper). Chlorfenapyr is lethal to rats with LD50 values of 441 and 1,152 mg/kg for male and female rats, respectively. Formulations containing chlorfenapyr have been used to control termites and in agriculture to control various insects.
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Uses
Chlorfenapyr is a halogenated pyrrole based pro-insecticide. Chlorfenapyr functions by metabolizing into an active insecticide after entering the host. Chlorfenapyr is used primarily as a means of pes
t control on cotton. Insecticide. Acaricide.
