di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate
CAS No.:1407507-02-1
Molecular Formula:C₂₈H₄₄FNO₆
Molecular Weight:509.659
Hs Code.:

Synonyms:di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

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Chemical Property of di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

Chemical Property:

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Technology Process of di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

There total 9 articles about di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.9%

: 1407506-24-4
di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[3-(tosyloxy)propyl]benzyl}-L-glutamate

: 1407507-02-1
di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

Guidance literature:: With tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; In acetonitrile; at 70 ℃; for 3.5h;

Reference yield:

: 770745-89-6
4-[3-(benzyloxy)propyl]benzaldehyde

: 1407507-02-1
di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

3.2: 2 h

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

5.1: pyridine / 2 h / 0 °C

6.1: tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride / acetonitrile / 3.5 h / 70 °C

With pyridine; sodium tetrahydroborate; ethanol; carbon tetrabromide; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; hydrogen; triphenylphosphine; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 433332-03-7
1-(3-benzyloxypropyl)-4-bromobenzene

: 1407507-02-1
di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C / Inert atmosphere

1.2: 0.5 h

2.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

4.2: 2 h

5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

6.1: pyridine / 2 h / 0 °C

7.1: tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride / acetonitrile / 3.5 h / 70 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; ethanol; carbon tetrabromide; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; hydrogen; triphenylphosphine; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; acetonitrile;