4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid

Base Information

Chemical Name:4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid
CAS No.:1407506-23-3
Molecular Formula:C₁₅H₂₀FNO₄
Molecular Weight:297.327
Hs Code.:

Synonyms:4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid

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Chemical Property of 4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid

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Technology Process of 4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid

There total 10 articles about 4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.3%

: 1407507-02-1
di-tert-butyl N-(tert-butoxycarbonyl)-4-[4-(3-fluoropropyl)benzyl]-L-glutamate

: 1407506-23-3
4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 24h;

Reference yield:

: 770745-89-6
4-[3-(benzyloxy)propyl]benzaldehyde

: 1407506-23-3
4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

3.2: 2 h

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

5.1: pyridine / 2 h / 0 °C

6.1: tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride / acetonitrile / 3.5 h / 70 °C

7.1: trifluoroacetic acid / 24 h / 20 °C

With pyridine; sodium tetrahydroborate; ethanol; carbon tetrabromide; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; hydrogen; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 433332-03-7
1-(3-benzyloxypropyl)-4-bromobenzene

: 1407506-23-3
4-[4-(3-fluoropropyl)benzyl]-L-glutamic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -75 °C / Inert atmosphere

1.2: 0.5 h

2.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

4.2: 2 h

5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

6.1: pyridine / 2 h / 0 °C

7.1: tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride / acetonitrile / 3.5 h / 70 °C

8.1: trifluoroacetic acid / 24 h / 20 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; ethanol; carbon tetrabromide; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; hydrogen; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; acetonitrile;