(R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate

Base Information

• Chemical Name: (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate
• CAS No.: 1638147-90-6
• Molecular Formula: C₁₈H₂₄N₂O₄
• Molecular Weight: 332.4

Synonyms:(R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate

Chemical Property of (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate

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Technology Process of (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate

There total 3 articles about (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one (1638147-86-0) → (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate (1638147-90-6)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at -20 ℃; for 36h; Inert atmosphere;

DOI:10.1002/ejoc.201402322

Reference yield:

(5R)-5,6-dihydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide (182316-01-4) → (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate (1638147-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / -20 - 0 °C / Inert atmosphere

2: hydrogenchloride / diethyl ether; methanol / 36 h / -20 °C / Inert atmosphere

With hydrogenchloride; In methanol; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.201402322

Reference yield:

1,2,5-trimethyl-1H-pyrrole (930-87-0) → (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate (1638147-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / -20 - 0 °C / Inert atmosphere

2: hydrogenchloride / diethyl ether; methanol / 36 h / -20 °C / Inert atmosphere

With hydrogenchloride; In methanol; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.201402322

upstream raw materials:

(5R)-5,6-dihydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide

1,2,5-trimethyl-1H-pyrrole

(3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one

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