(3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one

Base Information

• Chemical Name: (3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one
• CAS No.: 1638147-86-0
• Molecular Formula: C₁₇H₂₀N₂O₃
• Molecular Weight: 300.357
• Mol file: 1638147-86-0.mol

Synonyms:(3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one

Chemical Property of (3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one

There total 1 articles about (3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,2,5-trimethyl-1H-pyrrole (930-87-0) + (5R)-5,6-dihydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide (182316-01-4) → (3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one (1638147-86-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; at -20 - 0 ℃; for 3h; Temperature; Inert atmosphere;

DOI:10.1002/ejoc.201402322

Reference yield: 51.0%

(3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one (1638147-86-0) → (R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate (1638147-90-6)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at -20 ℃; for 36h; Inert atmosphere;

DOI:10.1002/ejoc.201402322

Reference yield:

(3R,5R)-4-hydroxy-5-phenyl-3-(1,2,5-trimethyl-1H-pyrrol-3-yl)morpholin-2-one (1638147-86-0) → C17H20N2O3

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; methanol / 36 h / -20 °C / Inert atmosphere

2: lead(IV) tetraacetate / dichloromethane; methanol / 1 h / 0 °C / Inert atmosphere

With hydrogenchloride; lead(IV) tetraacetate; In methanol; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.201402322

upstream raw materials:

1,2,5-trimethyl-1H-pyrrole

(5R)-5,6-dihydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide

Downstream raw materials:

(R)-methyl 2-(hydroxy((R)-2-hydroxy-1-phenylethyl)amino)-2-(1,2,5-trimethyl-1H-pyrrol-3-yl)acetate