(E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine

Base Information

Chemical Name:(E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine
CAS No.:1266477-07-9
Molecular Formula:C₂₀H₂₁N₅O
Molecular Weight:347.42
Hs Code.:

Synonyms:(E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine

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Chemical Property of (E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine

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Technology Process of (E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine

There total 6 articles about (E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 1266480-03-8
tert-butyl 5-cyclopropyl-3-(5-iodo-2-phenylpyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

: 165059-42-7,934342-48-0
(E)-3-methoxy-1-propenylboronic acid pinacol ester

: 1266477-07-9
(E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 15934-46-0
benzamidene hydrochloride

: 1266477-07-9
(E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / ethanol / 15 h / Reflux; Inert atmosphere

2.1: acetic acid; N-iodo-succinimide / 1 h / 50 °C

3.1: phosphorus(V) oxybromide / 8 h / 100 °C

4.1: butan-1-ol / 24 h / 90 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

5.2: 2 h / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; potassium carbonate; acetic acid; phosphorus(V) oxybromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil; butan-1-ol; 6.1: Suzuki Coupling;

Reference yield:

: 33643-94-6,127892-81-3
2-phenyl-4-hydroxypyrimidine

: 1266477-07-9
(E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; N-iodo-succinimide / 1 h / 50 °C

2.1: phosphorus(V) oxybromide / 8 h / 100 °C

3.1: butan-1-ol / 24 h / 90 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

4.2: 2 h / 20 °C

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; potassium carbonate; acetic acid; phosphorus(V) oxybromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; butan-1-ol; 5.1: Suzuki Coupling;