N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide

Base Information

Chemical Name:N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide
CAS No.:497096-52-3
Molecular Formula:C₁₇H₂₂N₂O₅
Molecular Weight:334.372
Hs Code.:

<i>N</i>-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-<i>c</i>]oxazol-7-yl]-<i>N</i>-methyl-acetamide

Synonyms:N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide

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Chemical Property of N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide

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Technology Process of N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide

There total 6 articles about N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: N-methoxy-3-{3-[2-(2-methoxy-phenyl)-ethyl]-2-oxo-oxazolidin-4-yl}-N-methyl-acrylamide

: 497096-52-3
N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide

Guidance literature:: With potassium fluoride; 2,2,2-Trifluoroacetophenone; In benzene; at 20 ℃; for 1h; UV-irradiation;
DOI:10.1016/S0040-4039(02)01817-8

Reference yield:

: 7417-18-7
2-methoxyphenethyl alcohol

: 497096-52-3
N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine

2.1: 83 percent / KH / dimethylformamide / 0 °C

3.1: O₃ / methanol

3.2: DMS

4.1: NaH / tetrahydrofuran

5.1: 41 percent / CF₃COPh; KF / benzene / 1 h / 20 °C / UV-irradiation

With pyridine; potassium fluoride; 2,2,2-Trifluoroacetophenone; potassium hydride; sodium hydride; ozone; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene; 4.1: Horner-Emmons reaction;
DOI:10.1016/S0040-4039(02)01817-8

Reference yield:

: 93-25-4
2-methoxyphenylacetic acid

: 497096-52-3
N-methoxy-2-[6-(2-methoxy-phenyl)-3-oxo-tetrahydro-pyrrolo[1,2-c]oxazol-7-yl]-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiAlH₄

2.1: pyridine

3.1: 83 percent / KH / dimethylformamide / 0 °C

4.1: O₃ / methanol

4.2: DMS

5.1: NaH / tetrahydrofuran

6.1: 41 percent / CF₃COPh; KF / benzene / 1 h / 20 °C / UV-irradiation

With pyridine; potassium fluoride; lithium aluminium tetrahydride; 2,2,2-Trifluoroacetophenone; potassium hydride; sodium hydride; ozone; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene; 5.1: Horner-Emmons reaction;
DOI:10.1016/S0040-4039(02)01817-8