7417-18-7

Usage

Uses

2-Methoxyphenethyl alcohol may be used in chemical synthesis.

InChI:InChI=1/C9H12O2/c1-11-9-5-3-2-4-8(9)6-7-10/h2-5,10H,6-7H2,1H3

Upstream product

• 33224-90-7 ethyl α-methoxy-α-phenylacetate 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 107-07-3 2-chloro-ethanol 
• 7768-28-7 2-(2-hydroxyphenyl)ethanol 
• 77-78-1 dimethyl sulfate 
• 75-21-8 oxirane 
• 100-66-3 methoxybenzene 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 93-25-4 2-methoxyphenylacetic acid 
• 7446-70-0 aluminium trichloride 
• 5339-85-5 2-aminophenethyl alcohol 
• 74-88-4 methyl iodide 
• 27798-60-3 methyl 2-(2-methoxyphenyl)acetate 
• 1072-53-3 ethyleneglycol sulfate 

Downstream Products

• 612-15-7 o-methoxystyrene 
• 35144-25-3 1-(2-methoxyphenyl)-ethyl chloride 
• 36449-75-9 1-(2-bromoethyl)-2-methoxybenzene 
• 163260-76-2 4-bromo-2-(2-bromo-ethyl)-anisole 
• 108840-41-1 1-(2-methoxy-phenyl)-2-(toluene-4-sulfonyloxy)-ethane 
• 90611-49-7 3,5-Dihydro-2-(2-hydroxyaethyl)-anisol 
• 32504-13-5 [2-(2-Methoxy-phenyl)-ethyl]-hydrazine 
• 496-16-2 2.3-dihydrobenzofuran 
• 57027-75-5 2-(2-Bromoethyl)phenol 
• 93-25-4 2-methoxyphenylacetic acid 
• 33567-59-8 (2-methoxy-phenyl)-acetaldehyde 
• 83605-16-7 1-[2-(methylsulfonyloxy)ethyl]-2-methoxybenzene 
• 85002-58-0 C₁₅H₁₅NO₄ 
• 79146-32-0 3-(2'-acetoxyethyl)-4-methoxyacetophenone 

Relevant academic research and scientific papers

Tropylium-Promoted Hydroboration Reactions: Mechanistic Insights Via Experimental and Computational Studies

Hydroboration reaction of alkynes is one of the most synthetically powerful tools to access organoboron compounds, versatile precursors for cross-coupling chemistry. This type of reaction has traditionally been mediated by transition-metal or main group catalysts. Herein, we report a novel method using tropylium salts, typically known as organic oxidants and Lewis acids, to promote the hydroboration reaction of alkynes. A broad range of vinylboranes can be easily accessed via this metal-free protocol. Similar hydroboration reactions of alkenes and epoxides can also be efficiently catalyzed by the same tropylium catalysts. Experimental studies and DFT calculations suggested that the reaction follows an uncommon mechanistic pathway, which is triggered by the hydride abstraction of pinacolborane with tropylium ion. This is followed by a series ofin situcounterion-activated substituent exchanges to generate boron intermediates that promote the hydroboration reaction.

BISPHENOLATE TRANSITION METAL COMPLEXES, PRODUCTION AND USE THEREOF

Bis phenolate transition metal complexes are disclosed for use in alkene polymerization, with optional chain transfer agent, to produce polyolefins.

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers

With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H+,K+-ATPase and can strongly bind to the K+-binding site, were designed based on a docking model. Among the compounds synthesized, compound 4d showed a strong H+,K+-ATPase-inhibitory activity and a high stomach concentration in rats, resulting in potent inhibitory action on histamine-stimulated gastric acid secretion in rats. Furthermore, 4d exerted significant inhibitory action on histamine-stimulated gastric-acid secretion in rats with a rapid onset and moderate duration of action after the administration. These findings may lead to a new insight into the drug design of potassium-competitive acid blockers.

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety

A series of CAPE derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE's antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50?=?0.4?±?0.02 & 0.6?±?0.03?μM against Hela and DU-145 respectively).

Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols

The "green" reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)3, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.

METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

Enantioselective hydrosilylation of aromatic alkenes catalyzed by chiral bis(oxazolinyl)phenyl-rhodium acetate complexes

Highly efficient and enantioselective hydrosilylation of aromatic alkenes catalyzed by the chiral rhodium acetate complexes with the bis(oxazolinyl)phenyl ligands has been reported that afforded chiral silane derivatives with up to 99% ee. Georg Thieme Ve

Novel, one-pot procedure for the synthesis of 2-arylethanol derivatives

An efficient one-pot synthesis of 2-arylethanol derivatives using ethylene sulfate as a C2 building block is described. High yields are obtained upon trapping of aryllithium intermediates generated by halogen-metal exchange or directed metalation with ethylene sulfate. The resulting heteroaryl or phenylethanol derivatives represent versatile building blocks for the synthesis of annulated pyran derivatives by oxa-Pictet-Spengler reaction.

Exploiting self-assembly for ligand-scaffold optimization: Substrate-tailored ligands for efficient catalytic asymmetric hydroboration

(Chemical Equation Presented) Mix and match: A self-assembled ligand library (SAL XY) affords a wide range of R/S ratios in Rh-catalyzed asymmetric hydroboration (see scheme; nbd = 2,5-norbornadiene, R* is a chiral substituent). Ligand-scaffold optimization reveals "substrate- tailored" ligands that afford high regio- and enantioselectivity for a variety of ortho-substituted styrene derivatives.