N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide

Base Information

Chemical Name:N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide
CAS No.:817160-15-9
Molecular Formula:C₁₇H₂₀N₂O₇S
Molecular Weight:396.421
Hs Code.:

Synonyms:N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide

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Chemical Property of N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide

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Technology Process of N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide

There total 4 articles about N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 817160-13-7
N-[2-(tert-butyldimethylsilanyloxymethyl)phenyl]-N-(2,2-dimethoxyethyl)-4-nitrobenzenesulfonamide

: 817160-15-9
N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2004.09.072

Reference yield:

: 68847-33-6
2-[(1,1,2,2-tetramethyl-1-silapropoxy)methyl]phenylamine

: 817160-15-9
N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / TEA / CH₂Cl₂ / 3 h / 20 °C

2: 80 percent / PPh₃; DIAD / tetrahydrofuran / 21 h / -20 - 30 °C

3: 90 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With di-isopropyl azodicarboxylate; TEA; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2004.09.072

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 817160-15-9
N-(2,2-dimethoxyethyl)-N-(2-hydroxymethylphenyl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / TEA / CH₂Cl₂ / 3 h / 20 °C

2: 80 percent / PPh₃; DIAD / tetrahydrofuran / 21 h / -20 - 30 °C

3: 90 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With di-isopropyl azodicarboxylate; TEA; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2004.09.072