(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

Base Information

Chemical Name:(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene
CAS No.:138505-82-5
Molecular Formula:C₂₈H₃₈O₃Si
Molecular Weight:450.693
Hs Code.:

Synonyms:(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

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Technology Process of (1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

There total 9 articles about (1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138523-70-3
(1S,2S,4aR,6R,8S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8-hydroxy-2-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid ethyl ester

: 138505-82-5
(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 1h; Yield given;
DOI:10.1021/jm00096a015

Reference yield:

: 138505-81-4
ethyl (1S,2S,4aR,6R,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dihydroxy-2-methylnaphthalene-1-carboxylate

: 138505-82-5
(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 16 h

2: LiAlH₄ / diethyl ether / 1 h

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00096a015

Reference yield:

: 138505-80-3
ethyl (1S,2S,4aR,6R,8S,8aS)-6-acetoxy-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene-1-carboxylate

: 138505-82-5
(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / sodium ethoxide / ethanol / 0.5 h

2: imidazole / dimethylformamide / 16 h

3: LiAlH₄ / diethyl ether / 1 h

With 1H-imidazole; lithium aluminium tetrahydride; sodium ethanolate; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00096a015