N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Base Information

Chemical Name:N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide
CAS No.:1361330-29-1
Molecular Formula:C₂₆H₂₆Cl₂N₄O₅S
Molecular Weight:577.488
Hs Code.:

Synonyms:N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

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Chemical Property of N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

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Technology Process of N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

There total 7 articles about N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 98-31-7
3,4-dichlorobenzenesulphonyl chloride

: 1361330-48-4
2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate

: 1361330-29-1
N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: 3,4-dichlorobenzenesulphonyl chloride; 2-{[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]amino}-1,1-dimethyl-2-oxoethyl acetate; With pyridine; In dichloromethane; at 20 ℃; for 0.55h;

With methanol; potassium carbonate; In dichloromethane; water; at 20 ℃;
DOI:10.1021/jm301572h

Reference yield:

: C₃₁H₃₄Cl₂N₄O₇S

: 1361330-29-1
N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: With methanol; potassium carbonate; at 20 ℃;

Reference yield:

: 94088-46-7
2-fluoro-6-methoxybenzonitrile

: 1361330-29-1
N-[(3-{[3-{[(3,4-dichlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

4: triethylamine / dichloromethane / 18 h / 20 °C

5: pyridine / dichloromethane / 0.33 h / 20 °C

6: potassium carbonate; methanol / 20 °C

With pyridine; methanol; lithium aluminium tetrahydride; potassium carbonate; hydrazine hydrate; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; butan-1-ol;