N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide

Base Information

• Chemical Name: N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide
• CAS No.: 1609152-90-0
• Molecular Formula: C₂₂H₁₉Cl₂N₃O₆
• Molecular Weight: 492.315
• Mol file: 1609152-90-0.mol

Synonyms:N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide

Chemical Property of N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide

There total 4 articles about N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 3-(3-chloropropox y)-N-(3,5-dichloropyridin-4-yl) - 4-methoxybenzamine (1185160-66-0) → N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide (1609152-90-0)

Guidance literature:

3-(3-chloropropox y)-N-(3,5-dichloropyridin-4-yl) - 4-methoxybenzamine; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-nitro-phenol; In N,N-dimethyl-formamide; at 75 ℃; for 10h;

DOI:10.3184/174751913X13782291519608

Reference yield:

isovanillin (621-59-0) → N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide (1609152-90-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 10 h / 75 °C

2.1: aminosulfonic acid; acetic acid; sodium chlorite / water / 1 h / 0 - 5 °C / Cooling with ice

3.1: thionyl chloride / 2 h / Reflux

4.1: sodium hydride / tetrahydrofuran / 5 h / 15 - 25 °C

5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 10 h / 75 °C

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.3184/174751913X13782291519608

Reference yield:

3-(3-chloropropoxy)-4-methoxybenzaldehyde (929683-54-5) → N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-(4-nitrophenoxy)propoxy)benzamide (1609152-90-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aminosulfonic acid; acetic acid; sodium chlorite / water / 1 h / 0 - 5 °C / Cooling with ice

2.1: thionyl chloride / 2 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 5 h / 15 - 25 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 10 h / 75 °C

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.3184/174751913X13782291519608

upstream raw materials:

4-nitro-phenol

3-(3-chloropropox y)-N-(3,5-dichloropyridin-4-yl) - 4-methoxybenzamine

isovanillin

3-(3-chloropropoxy)-4-methoxybenzaldehyde