5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

Base Information

Chemical Name:5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine
CAS No.:600736-38-7
Molecular Formula:C₄₃H₄₆N₆O₁₀SSi
Molecular Weight:867.024
Hs Code.:

Synonyms:5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

Chemical Property:

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Technology Process of 5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

There total 4 articles about 5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 600736-37-6
5'-O-dimethoxytityl-6-(2,4-dinitrophenyl)thioinosine

: 5'-O-dimethoxytityl-2'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

: 600736-38-7
5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

: 5'-O-dimethoxytityl-2',3'-bis-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1016/S0968-0896(03)00060-9

Reference yield:

: 70-34-8,65727-75-5
2,4-Dinitrofluorobenzene

: 600736-38-7
5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / triethylamine / acetonitrile / 1 h / 20 °C

2: 84 percent / pyridine; 4-(dimethylamino)pyridine; triethylamine / 22.5 h

3: 51 percent / imidazole / dimethylformamide / 17 h / 20 °C

With pyridine; 1H-imidazole; dmap; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(03)00060-9

Reference yield:

: 574-25-4
6-thioinosine

: 600736-38-7
5'-O-dimethoxytityl-3'-O-(tert-butyldimethylsilyl)-6-(2,4-dinitrophenyl)thioinosine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / triethylamine / acetonitrile / 1 h / 20 °C

2: 84 percent / pyridine; 4-(dimethylamino)pyridine; triethylamine / 22.5 h

3: 51 percent / imidazole / dimethylformamide / 17 h / 20 °C

With pyridine; 1H-imidazole; dmap; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(03)00060-9