N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide

Base Information

Chemical Name:N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide
CAS No.:130260-00-3
Molecular Formula:C₂₃H₃₁N₃O₄S
Molecular Weight:445.583
Hs Code.:

Synonyms:N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide

There total 5 articles about N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 130259-96-0
N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-(4-toluenesulfonyl)-amino)benzamide

: 77-78-1
dimethyl sulfate

: 130260-00-3
N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide

Guidance literature:: With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; for 1h; Ambient temperature;

Reference yield:

: 6789-94-2
1-ethylpiperidin-3-amine

: 130260-00-3
N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / CHCl₃ / 1.5 h / Heating

2: 82 percent / N₂H₄*H₂O, Raney Ni / ethanol / 1.5 h / 60 °C

3: 94 percent / NaHCO₃ / CH₂Cl₂

4: 67 percent / tetrabutylamonium hydrogen sulfate, KOH / CH₂Cl₂; H₂O / 1 h / Ambient temperature

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; nickel; sodium hydrogencarbonate; hydrazine hydrate; In ethanol; dichloromethane; chloroform; water;

Reference yield:

: 90763-46-5
2-methoxy-5-nitrobenzoyl chloride

: 130260-00-3
N-(1-ethyl-3-piperidinyl)-2-methoxy-5-(N-methyl-N-(4-toluenesulfonyl)amino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / CHCl₃ / 1.5 h / Heating

2: 82 percent / N₂H₄*H₂O, Raney Ni / ethanol / 1.5 h / 60 °C

3: 94 percent / NaHCO₃ / CH₂Cl₂

4: 67 percent / tetrabutylamonium hydrogen sulfate, KOH / CH₂Cl₂; H₂O / 1 h / Ambient temperature

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; nickel; sodium hydrogencarbonate; hydrazine hydrate; In ethanol; dichloromethane; chloroform; water;