Technology Process of PBO 269
There total 5 articles about PBO 269 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-m-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-one;
With
potassium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 1.5h;
ethyl iodide;
In
tetrahydrofuran;
at 20 ℃;
for 15h;
DOI:10.1021/jm990150o
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / tetrahydrofuran / 1 h / 20 °C
1.2: tetrahydrofuran / 16 h / 20 °C
2.1: 5 percent aq. NaOH / ethanol / 17 h / 20 °C
3.1: PCl5 / 5 h / 20 °C
4.1: KH / tetrahydrofuran / 1.5 h / 20 °C
4.2: tetrahydrofuran / 15 h / 20 °C
With
sodium hydroxide; phosphorus pentachloride; potassium hydride; sodium hydride;
In
tetrahydrofuran; ethanol;
1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Cyclization / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1021/jm990150o
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / tetrahydrofuran / 1 h / 20 °C
1.2: tetrahydrofuran / 16 h / 20 °C
2.1: 5 percent aq. NaOH / ethanol / 17 h / 20 °C
3.1: PCl5 / 5 h / 20 °C
4.1: KH / tetrahydrofuran / 1.5 h / 20 °C
4.2: tetrahydrofuran / 15 h / 20 °C
With
sodium hydroxide; phosphorus pentachloride; potassium hydride; sodium hydride;
In
tetrahydrofuran; ethanol;
1.1: Metallation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Cyclization / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1021/jm990150o
