2-thiophenecarbaldehyde N-phenylthiosemicarbazone

Base Information

Chemical Name:2-thiophenecarbaldehyde N-phenylthiosemicarbazone
CAS No.:199187-74-1
Molecular Formula:C₁₂H₁₁N₃S₂
Molecular Weight:261.371
Hs Code.:
European Community (EC) Number:657-329-3
ChEMBL ID:CHEMBL3260043

Synonyms:2-thiophenecarbaldehyde N-phenylthiosemicarbazone;CHEMBL3260043;STK042414;AKOS002663119;(2E)-N-phenyl-2-(thiophen-2-ylmethylidene)hydrazinecarbothioamide

Suppliers and Price of 2-thiophenecarbaldehyde N-phenylthiosemicarbazone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-thiophenecarbaldehyde N-phenylthiosemicarbazone

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:261.03943971
Heavy Atom Count:17
Complexity:275

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)NC(=S)NN=CC2=CC=CS2
Isomeric SMILES:C1=CC=C(C=C1)NC(=S)N/N=C/C2=CC=CS2

Technology Process of 2-thiophenecarbaldehyde N-phenylthiosemicarbazone

There total 2 articles about 2-thiophenecarbaldehyde N-phenylthiosemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 98-03-3
thiophene-2-carbaldehyde

: 5351-69-9
4-Phenyl-3-thiosemicarbazide

: 199187-74-1
(E)-N-phenyl-2-(thiophen-2-ylmethylene)hydrazine-1-carbothioamide

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm500018m

Reference yield:

: 62-53-3
aniline

: 199187-74-1
(E)-N-phenyl-2-(thiophen-2-ylmethylene)hydrazine-1-carbothioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 20 °C

1.2: 0.3 h / 20 °C

2.1: hydrazine hydrate / methanol / Reflux

3.1: acetic acid / methanol / 2 h / Reflux

With hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2020.112349