tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

Base Information

Chemical Name:tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate
CAS No.:1354910-18-1
Molecular Formula:C₁₇H₂₀N₂O₄
Molecular Weight:316.357
Hs Code.:

Synonyms:tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

Suppliers and Price of tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

Chemical Property:

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Technology Process of tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

There total 18 articles about tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354910-36-3
2-(4-bromo-phenyl)-6,7-dihydro-4H-oxazolo[4,5-c]pyridine-5-carboxylic acid t-butyl ester

: 1354910-18-1
tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; at 80 ℃; for 16h;

Reference yield:

: tert-butyl 2-(4-acetoxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

: 1354910-18-1
tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: With hydrogenchloride; sodium hydroxide; In water;

Reference yield:

: 586-75-4
4-chlorobenzoyl chloride

: 1354910-18-1
tert-butyl 2-(4-hydroxyphenyl)-6,7-dihydrooxazolo[4,5-c]pyridine-5(4H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 64 h / 20 °C

3.1: N,N-dimethyl-formamide / 16 h

4.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C

4.2: 0.08 h

5.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 2.17 h / 0 °C / Reflux

5.2: 48 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane / 16 h / 80 °C

With sodium tetrahydroborate; hexachloroethane; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;