5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine

Base Information

Chemical Name:5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine
CAS No.:317820-41-0
Molecular Formula:C₃₀H₃₉N₃O₇Si
Molecular Weight:581.741
Hs Code.:

Synonyms:5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine

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Chemical Property of 5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine

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Technology Process of 5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine

There total 8 articles about 5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 317820-41-0
5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / pyridine / 20 °C

2: 50 percent / BH₃ / tetrahydrofuran / 150 °C

3: 86 percent / PPh₃; DEAD / tetrahydrofuran

4: N-methylhydrazine / CH₂Cl₂ / -10 - 0 °C

5: methanol

With borane; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1: silylation / 2: Ring cleavage / 3: Condensation / 4: Hydrolysis / 5: Condensation;
DOI:10.1021/ol006555g

Reference yield:

: 75-07-0,9002-91-9
acetaldehyde

: 212061-25-1
5'-O-(tert-butyldiphenylsilyl)-2'-O-[2-[(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)oxy]ethyl]-5-methyluridine

: 317820-41-0
5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine

Guidance literature:: 5'-O-(tert-butyldiphenylsilyl)-2'-O-[2-[(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)oxy]ethyl]-5-methyluridine; With methylhydrazine; In dichloromethane; at -10 - 0 ℃; for 1h;

acetaldehyde; In methanol; at 20 ℃; for 12h;

Reference yield:

: 212061-24-0
5'-O-(tert-butyldiphenylsilyl)-2'-O-(2-hydroxyethyl)-5-methyluridine

: 317820-41-0
5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / PPh₃; DEAD / tetrahydrofuran

2: N-methylhydrazine / CH₂Cl₂ / -10 - 0 °C

3: methanol

With triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 1: Condensation / 2: Hydrolysis / 3: Condensation;
DOI:10.1021/ol006555g