5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine
CAS No.:317820-44-3
Molecular Formula:C₃₇H₄₅N₃O₉
Molecular Weight:675.779
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

Suppliers and Price of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 317820-43-2
2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

: 317820-44-3
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

Guidance literature:: With dmap; In pyridine; at 20 ℃;
DOI:10.1021/ol006555g

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 317820-44-3
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / pyridine / 20 °C

2: 50 percent / BH₃ / tetrahydrofuran / 150 °C

3: 86 percent / PPh₃; DEAD / tetrahydrofuran

4: N-methylhydrazine / CH₂Cl₂ / -10 - 0 °C

5: methanol

6: PPTS; NaCNBH₃ / methanol

7: PPTS; NaCNBH₃ / methanol

8: 74 percent / HF₃*TEA; TEA / tetrahydrofuran

9: 87 percent / DMAP / pyridine / 20 °C

With dmap; HF₃*TEA; TEA; borane; pyridinium p-toluenesulfonate; sodium cyanoborohydride; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1: silylation / 2: Ring cleavage / 3: Condensation / 4: Hydrolysis / 5: Condensation / 6: Reduction / 7: Condensation / 8: desilylation / 9: tritylation;
DOI:10.1021/ol006555g

Reference yield:

: 171763-19-2
5'-O-tert-butyldiphenylsilyl-O²-2'-anhydro-5-methyluridine

: 317820-44-3
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / BH₃ / tetrahydrofuran / 150 °C

2: 86 percent / PPh₃; DEAD / tetrahydrofuran

3: N-methylhydrazine / CH₂Cl₂ / -10 - 0 °C

4: methanol

5: PPTS; NaCNBH₃ / methanol

6: PPTS; NaCNBH₃ / methanol

7: 74 percent / HF₃*TEA; TEA / tetrahydrofuran

8: 87 percent / DMAP / pyridine / 20 °C

With dmap; HF₃*TEA; TEA; borane; pyridinium p-toluenesulfonate; sodium cyanoborohydride; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1: Ring cleavage / 2: Condensation / 3: Hydrolysis / 4: Condensation / 5: Reduction / 6: Condensation / 7: desilylation / 8: tritylation;
DOI:10.1021/ol006555g