6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide

Base Information

Chemical Name:6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide
CAS No.:1373887-50-3
Molecular Formula:C₂₀H₁₉Cl₂N₃O
Molecular Weight:388.296
Hs Code.:

Synonyms:6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide

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Chemical Property of 6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide

Chemical Property:

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Technology Process of 6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide

There total 3 articles about 6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1373887-63-8
6-chloro-4-(4-chlorophenyl)-N-isobutylquinazoline-2-carboxamide

: 74-88-4
methyl iodide

: 1373887-50-3
6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide

Guidance literature:: 6-chloro-4-(4-chlorophenyl)-N-isobutylquinazoline-2-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm201703k

Reference yield:

: 1373887-66-1
6-chloro-4-(4-chlorophenyl)quinazoline-2-carboxylic acid

: 1373887-50-3
6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Cooling with ice; Inert atmosphere

3.2: 1 h / 25 °C / Inert atmosphere

With thionyl chloride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm201703k

Reference yield:

: 1373887-69-4
C₁₅H₁₀Cl₂N₂O₂

: 1373887-50-3
6-chloro-4-(4-chlorophenyl)-N-isobutyl-N-methylquinazoline-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 12 h / 20 °C / Irradiation

2.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

3.1: triethylamine / tetrahydrofuran / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Cooling with ice; Inert atmosphere

4.2: 1 h / 25 °C / Inert atmosphere

With thionyl chloride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm201703k