2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

Base Information

Chemical Name:2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid
CAS No.:1434632-94-6
Molecular Formula:C₂₄H₂₂F₃N₃O₆S
Molecular Weight:537.516
Hs Code.:

Synonyms:2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

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Chemical Property of 2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

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Technology Process of 2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

There total 12 articles about 2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434644-41-3
C₂₄H₂₂F₃N₃O₆S

: 1434632-94-6
2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

: 1434632-88-8
(S)-2-methyl-2-(5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1-(2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl)-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)propanoic acid

Guidance literature:: With Chiralpak IC; In ethanol; hexane;

Reference yield:

: 4815-30-9
diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate

: 1434632-94-6
2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

: 1434632-88-8
(S)-2-methyl-2-(5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1-(2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl)-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / 1,4-dioxane / 0.25 h / 10 °C

1.2: 10 - 100 °C

2.1: sodium hydroxide; water / methanol / 4 h / 50 °C

3.1: potassium carbonate; silver(I) acetate; 1-methyl-pyrrolidin-2-one / 2 h / 110 °C

4.1: bromine; CH₃COONa / acetic acid / 1 h / 20 °C

5.1: Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

8.1: Chiralpak IC / ethanol; hexane

With 1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; CH₃COONa; water; bromine; silver(I) acetate; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; acetic acid; toluene;

Reference yield:

: 1434655-18-1
tert-butyl 2-isocyanato-2-methylpropanoate

: 1434632-94-6
2-methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

: 1434632-88-8
(S)-2-methyl-2-(5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1-(2-phenyl-2-(2,2,2-trifluoroethoxy)ethyl)-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / 1,4-dioxane / 0.25 h / 10 °C

1.2: 10 - 100 °C

2.1: sodium hydroxide; water / methanol / 4 h / 50 °C

3.1: potassium carbonate; silver(I) acetate; 1-methyl-pyrrolidin-2-one / 2 h / 110 °C

4.1: bromine; CH₃COONa / acetic acid / 1 h / 20 °C

5.1: Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 110 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

8.1: Chiralpak IC / ethanol; hexane

With 1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; CH₃COONa; water; bromine; silver(I) acetate; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; acetic acid; toluene;