(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid

Base Information

Chemical Name:(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid
CAS No.:1428527-53-0
Molecular Formula:C₁₆H₁₄N₅O₅P
Molecular Weight:387.291
Hs Code.:

Synonyms:(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid

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Chemical Property of (4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid

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Technology Process of (4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid

There total 8 articles about (4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1428527-52-9
diisopropyl (4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl phosphonate

: 1428527-53-0
(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 100-52-7
benzaldehyde

: 1428527-53-0
(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 48 h / 20 - 60 °C / Molecular sieve

2: triethylamine / dichloromethane / 25 °C

3: trimethylsilyl bromide / dichloromethane / 0 - 20 °C / Inert atmosphere

With trimethylsilyl bromide; ammonium acetate; triethylamine; In ethanol; dichloromethane;

Reference yield:

: 53896-49-4
pyridazine-3-carbonitrile

: 1428527-53-0
(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 20 °C

1.2: 3 h / Reflux

2.1: sodium methylate / methanol / Reflux

2.2: 4 h / Reflux

3.1: thionyl chloride / Reflux

4.1: triethylamine / dichloromethane / 25 °C

5.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C / Inert atmosphere

With thionyl chloride; trimethylsilyl bromide; sodium methylate; triethylamine; In methanol; dichloromethane;