6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine

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Chemical Name:6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine
CAS No.:1428249-23-3
Molecular Formula:C₂₄H₂₃F₄N₇S
Molecular Weight:517.553
Hs Code.:

Synonyms:6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine

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Chemical Property of 6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine

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Technology Process of 6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine

There total 3 articles about 6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1218791-01-5
methyl‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)‐1,3‐thiazole

: 1428248-69-4
5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

: 1428249-23-3
6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; Sealed tube; Microwave irradiation;
DOI:10.1016/j.bmcl.2021.128352

Reference yield:

: 1083051-56-2
6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

: 1428249-23-3
6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / Microwave irradiation

2: palladium diacetate; caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 100 °C / Sealed tube; Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; caesium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2021.128352

Reference yield:

: 1428249-23-3
6-(4-{4-[4-Fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-(2-methyl-1,3-thiazol-5-yl)pyrimidin-4-amine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; acetone;