Tocofersolan

Base Information

• Chemical Name: Tocofersolan
• CAS No.: 9002-96-4
• Molecular Formula: C₄₅H₇₈O₁₁
• Molecular Weight: 795.108
• ChEMBL ID: CHEMBL2355578
• DSSTox Substance ID: DTXSID90872278
• Nikkaji Number: J3.265.700A
• Pharos Ligand ID: 85BJCGZ83ZT5
• Wikipedia: Tocofersolan
• Mol file: 9002-96-4.mol

Synonyms:(+)-alpha-tocopheryl polyethylene glycol 1000 succinate;alpha-D-tocopherol poly(ethylene glycol) 2000 succinate;alpha-tocopheryl polyethylene glycol succinate;mono-(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) succinate polyethylene glycol monoester;poly(oxy-1,2-ethanediyl), alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl-omega-hydroxy-;tocofersolan;tocopherol poly(ethylene glycol) 2000 succinate;tocopherol polyethylene glycol succinate;tocophersolan;tocophersolan, (2R-(2R*(4R*,8R*)))-isomer;tocopheryl poly(ethylene glycol) 1000 succinate;TPGS;TPGS 2K;vitamin E-TPGS;vitamine E PEG-1000-succinate

Chemical Property of Tocofersolan

Chemical Property:

• Appearance/Colour: Clear, colorless solid.
• Vapor Pressure: 1.83E-18mmHg at 25°C
• Melting Point: 34-38oC
• Refractive Index: 1.496
• Boiling Point: 662.7oC at 760mmHg
• Flash Point: 195.4oC
• PSA: 100.52000
• Density: 1.01g/cm3
• LogP: 8.38890
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble1g/10 mL, clear to faintly turbid, colorless to fain
• XLogP3: 9.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 20
• Exact Mass: 574.42333957
• Heavy Atom Count: 41
• Complexity: 768

Purity/Quality:

Tocofersolan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C
• Isomeric SMILES: CC1=C(C(=C(C2=C1O[C@](CC2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C
• Recent ClinicalTrials: Use of Tocofersolan (Vedrop?) to Prevent or Treat Refractive Vitamin E Deficiency in Infants and Children
• Recent EU Clinical Trials: VEDROP: Etude de l’absorption de la Vitamine E sous une forme hydrosoluble (pégylée) dans les hypocholestérolémies familiales par retention de chylomicrons
• Uses: Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e. Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21

Technology Process of Tocofersolan

There total 1 articles about Tocofersolan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.33%

pentaethylene glycol (2615-15-8) + vitamin E succinate (4345-03-3) → hexa(ethylene glycol) tocopherol succinate (850655-03-7,9002-96-4)

Guidance literature:

pentaethylene glycol; vitamin E succinate; In toluene;

With dmap; dicyclohexyl-carbodiimide; In chloroform;

upstream raw materials:

pentaethylene glycol

vitamin E succinate