4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide
CAS No.:1382801-49-1
Molecular Formula:C₁₈H₁₈Cl₂F₃N₂O₄PS
Molecular Weight:517.293
Hs Code.:

Synonyms:4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide

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Chemical Property of 4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide

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Technology Process of 4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide

There total 4 articles about 4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 110-91-8,99108-56-2
morpholine

: 1382801-48-0
[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]methylphosphinic acid

: 1382801-49-1
4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 6828-35-9
5-chloro-2-iodoaniline

: 1382801-49-1
4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 100 °C

2: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 110 °C / sealed tube

3: 1-(Trimethylsilyl)imidazole / chloroform / 0.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With pyridine; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 1-(Trimethylsilyl)imidazole; copper(l) iodide; N,N`-dimethylethylenediamine; In chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: 32333-53-2
4-chloro-3-trifluoromethylbenzenesulfonyl chloride

: 1382801-49-1
4-Chloro-N-{5-chloro-2-[methyl(morpholin-4-yl)phosphoryl]phenyl}-3-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 100 °C

2: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 110 °C / sealed tube

3: 1-(Trimethylsilyl)imidazole / chloroform / 0.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

With pyridine; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 1-(Trimethylsilyl)imidazole; copper(l) iodide; N,N`-dimethylethylenediamine; In chloroform; N,N-dimethyl-formamide; toluene;