4-METHYL-N-(3-OXO-3-(PYRROLIDIN-1-YL)PROPYL)BENZENESULFONAMIDE

Base Information

• Chemical Name: 4-METHYL-N-(3-OXO-3-(PYRROLIDIN-1-YL)PROPYL)BENZENESULFONAMIDE
• CAS No.: 122081-15-6
• Molecular Formula: C₁₄H₂₀N₂O₃S
• Molecular Weight: 296.39
• Mol file: 122081-15-6.mol

Synonyms:3-{[(4-methylphenyl)sulfonyl]amino}-1-pyrrolidinylpropan-1-one

Chemical Property of 4-METHYL-N-(3-OXO-3-(PYRROLIDIN-1-YL)PROPYL)BENZENESULFONAMIDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-N-(3-oxo-3-(pyrrolidin-1-yl)propyl)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-METHYL-N-(3-OXO-3-(PYRROLIDIN-1-YL)PROPYL)BENZENESULFONAMIDE

There total 4 articles about 4-METHYL-N-(3-OXO-3-(PYRROLIDIN-1-YL)PROPYL)BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidine (123-75-1) + N-(toluene-4-sulfonyl)-β-alanyl chloride (61341-03-5) → 3-{[(4-methylphenyl)sulfonyl]amino}-1-pyrrolidinylpropan-1-one (122081-15-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

Reference yield:

3-{[(4-methylphenyl)sulfonyl]amino}propanoic acid (42908-33-8) → 3-{[(4-methylphenyl)sulfonyl]amino}-1-pyrrolidinylpropan-1-one (122081-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2.5 h / Reflux

2: dichloromethane / 2 h / 20 °C

With thionyl chloride; In dichloromethane;

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 3-{[(4-methylphenyl)sulfonyl]amino}-1-pyrrolidinylpropan-1-one (122081-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water / 1 h / 70 °C

2: thionyl chloride / 2.5 h / Reflux

3: dichloromethane / 2 h / 20 °C

With thionyl chloride; sodium hydroxide; In dichloromethane; water;

upstream raw materials:

pyrrolidine

3-{[(4-methylphenyl)sulfonyl]amino}propanoic acid

p-toluenesulfonyl chloride

N-(toluene-4-sulfonyl)-β-alanyl chloride

Downstream raw materials:

3-[(4-methylphenyl)sulfonyl]-3-azabicyclo[3.2.0]heptan-6-one

3-{[(4-methylphenyl)sulfonyl]-N-(prop-2-en-1-yl)amino}-1-pyrrolidinylpropan-1-one

3-[(4-methylphenyl)sulfonyl]-3-azabicyclo[4.2.0]octan-8-one

(1R,5S,7R)-7-Methyl-3-(toluene-4-sulfonyl)-3-aza-bicyclo[3.1.1]heptan-6-one