7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one
• CAS No.: 243665-94-3
• Molecular Formula: C₁₈H₁₁ClFN₃O
• Molecular Weight: 339.756

Synonyms:7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Chemical Property of 7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Chemical Property:

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Technology Process of 7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

There total 2 articles about 7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

formic acid (64-18-6) + 2-amino-1-(3-chloro-4-fluoro-phenyl)-4-phenyl-1H-pyrrole-3-carbonitrile (243665-81-8) → 7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one (243665-94-3)

Guidance literature:

Heating;

DOI:10.1002/jhet.5570360325

Reference yield:

2-bromo-1-phenylethylidenemalononitrile (4651-78-9) → 7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one (243665-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / propan-2-ol / 1 h / 60 - 65 °C

2: 68 percent / Heating

In isopropyl alcohol;

DOI:10.1002/jhet.5570360325

Reference yield: 90.0%

7-(3-chloro-4-fluoro-phenyl)-5-phenyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one (243665-94-3) → 4-chloro-7-(3-chloro-4-fluoro-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine (243666-00-4)

Guidance literature:

With trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; Heating;

upstream raw materials:

formic acid

2-amino-1-(3-chloro-4-fluoro-phenyl)-4-phenyl-1H-pyrrole-3-carbonitrile

2-bromo-1-phenylethylidenemalononitrile

Downstream raw materials:

4-chloro-7-(3-chloro-4-fluoro-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

[7-(3-chloro-4-fluoro-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

C₂₁H₁₆Cl₂FN₃O

C₂₁H₁₇ClFN₃O

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