benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate

Base Information

• Chemical Name: benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate
• CAS No.: 1332360-40-3
• Molecular Formula: C₂₆H₃₀N₄O₈S
• Molecular Weight: 558.612
• Mol file: 1332360-40-3.mol

Synonyms:benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate

Chemical Property of benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate

There total 2 articles about benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)butanoic acid (10312-42-2) + (S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate (66025-93-2) → benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate (1332360-40-3)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In acetonitrile; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2011.05.042

Reference yield:

tert-butoxycarbonyl-L-alanyl-D-isoglutamine benzyl ester (18814-49-8) → benzyl (4R)-5-amino-5-oxo-4-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanoate (1332360-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 0 - 20 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / acetonitrile / 3 h / 0 - 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2011.05.042

upstream raw materials:

4-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)butanoic acid

(S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

tert-butoxycarbonyl-L-alanyl-D-isoglutamine benzyl ester